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Across those studies, doses vary quite a bit often ranging from 600mg to 1,800mg per day, depending on the condition being studied.1 10 20 22 That range is one reason we like 600mg capsules for most people

N., Ock S

Thiol-based regulation of redox-active glutamatecysteine ligase from Arabidopsis thaliana

Journal of Immunology Research , 2021 , 1-9

If you have a methylation issue then you will want to use methylcobalamin

However, this chemical process includes complex reaction processes and low yield, resulting in high cost and low purity of -EC, limiting the production of -EC for physical function investigations and medical/pharmaceutical applications