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The symptom does not necessarily indicate treatment failure or a serious underlying problem, but rather reflects the medication's expected pharmacological effect on gastrointestinal motility

While missing one weekly dose of a GLP-1 or GIP/GLP-1 receptor agonist is generally not medically dangerous, prolonged interruption can lead to return of appetite, potential weight regain, and in patients with type 2 diabetes, deterioration of glycemic control

Accusations against the manufacturer include that they knew of the increased risk for adverse health issues, especially with long-term use, and failed to adequately warn consumers

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However, after incorporating mortality improvement associated with device use, T1DM mortality decreased to around twice that of the overall population (2.0%, 2.0%, and 2.1% in Years 1, 5, and 10, respectively)