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Expansion of adipose tissue increases expression of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1), which converts inactive cortisone to active cortisol, thereby amplifying cortisol exposure in local tissues [82, 83]

(Stefanello et al., 2009)

World J Microbiol Biotechnol 33:106119 Acknowledgements The authors are grateful to Dr

Search Strategy In order to answer the clinical question, literature search on Clinical Key, Cochrane, Journal of the American Academy of Dermatology, Taylor and Francis Online, Pubmed, and ScienceDirect databases on June 3 rd , 2018, was conducted

PMID: 177 LiuWYouDLinJZouHZhangLLuoSet al

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