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A 2019 safety review noted that some animal toxicology studies used doses of 10003000 mg/kg body weightlevels high enough to produce genetic damage in test animals

10.1093/carcin/bgy038 31 SassoliC.PiniA.ChelliniF.MazzantiB.NistriS.NosiD.et al (2012)

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A small increase in blood microbiota-derived LPS has been identified as a key factor in triggering low-grade inflammation, leading to insulin resistance in obesity-related cardiometabolic disorders 90

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