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Drug compounding defined by the FDA as the process of combining, mixing or altering ingredients of a drug to create a medication tailored to a patients needs was the primary way drugs were produced until large-scale pharmaceutical manufacturing emerged early in the 20th century

2026 Jan;32(1):353-361

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For context, NICE has issued technology appraisals for semaglutide (Wegovy) for weight management and for tirzepatide (Mounjaro) for weight management, each with specific eligibility criteria based on BMI and the presence of weight-related comorbidities

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