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Sections hybridized for Glp1r were incubated overnight in the cocktail of the Guinea pig NeuN antiserum and either a rabbit antiserum against polycystin-L (PKD2L1) (Millipore, Cat# AB9084, 1:500) or a mouse monoclonal antibody against GFAP (Millipore, Cat# MAB360, 1:4000)

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This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population (63, 64)

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Phytotherapy Research , 33 (7), 19211933