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MC3R and MC4R are more connected to energy balance, appetite, autonomic tone, and central nervous system regulation

Prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

A common protocol: 15 mg 10 mg 5 mg for tirzepatide, or 2.4 mg 1.7 mg 1.0 mg for semaglutide, holding for several weeks at each level and watching the scale

Mah C, Loetscher E, Dev KK, Bobirnac I, Otten U, Schoeffter P