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Academic Press, p 175202

The study used a randomized, double-blind, placebo-controlled, crossover-designed trial and concluded, oral nicotinamide riboside increased human skeletal muscle NAAD, a sensitive marker of increased NAD+ metabolism. Seventh Human Niagen Study That Demonstrates Effectiveness: A study published in The American Journal of Clinical Nutrition in 2020 investigated the effects of Niagen on metabolic health, muscle metabolism, and mitochondrial function

Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses