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Prior to metabolism in the mitochondria, the acetyl group is transferred to coenzyme A (CoA) to form acetyl-CoA, which enters the TCA cycle to generate ATP through oxidative phosphorylation

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21 Similarly, Wilding et al demonstrated that in overweight or obese participants receiving 2.4 mg semaglutide, both total and regional visceral fat mass decreased, whereas lean body mass increased

These trials showed that Retatrutides activation of GLP-1, GIP, and glucagon receptors can improve metabolic balance, enhance fat oxidation, and support weight management outcomes in study populations

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