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Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), people following vegan or strict vegetarian diets (as B12 is naturally found almost exclusively in animal products), individuals with pernicious anaemia or other malabsorption conditions, those taking certain medications such as metformin or proton pump inhibitors long-term, and people with significant nitrous oxide exposure (including recreational use), which can inactivate B12 in the body

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Later studies showed that the colloidal particles in milk known as casein micelles represent a complex aggregate of individual casein proteins, stabilized by calcium phosphate (Svedberg and Pedersen, 1940)

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Signs You May Benefit from B12 Supplementation Several evidence-based indicators suggest when B12 injections might help your athletic performance

Sometimes it feels like electricity running down the back of the thigh or into the calf