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Understanding Titration Schedules and Your Dose May Go Up A standard semaglutide titration schedule progresses as follows: week 1-4 at 0.25 mg, weeks 5-8 at 0.5 mg, weeks 9-12 at 1.0 mg, weeks 13-16 at 1.7 mg, and weeks 17+ at 2.4 mg

According to the Wegovy SmPC, treatment should be reviewed after 6 months at the maintenance dose (2.4 mg or maximum tolerated dose)

Why 46 hours specifically

This medication has a long list of contraindications and cautionary prescribing, including MAO inhibitor use within 14 days, seizure disorder, hypertension, and patients under age 25

Hum Reprod 12 , 11421151 (1997)

Understanding the importance of adherence to the prescribed dosing schedule cannot be overstated