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The peptide activates endothelial nitric oxide synthase (eNOS) through both VEGFR2-dependent and VEGFR2-independent pathways

Chong Y, Ikematsu H, Yamaji K, Nishimura M, Kashiwagi S, Hayashi J

Decreased activity of the mitochondrial respiratory chain was reported in overweight/obese patients with NASH compared to controls [97, 98], and alterations in mitochondrial ultrastructure have been observed prior to NAFLD development in the Otsuka LongEvans Tokushima Fatty rat [99] as well as in patients with steatosis preceding progression to NASH [100]

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