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The SUMMIT trial took this further with tirzepatide, showing a 38% reduction in the composite of cardiovascular death or worsening heart failure (HR 0.62) in patients with HFpEF and obesity, along with a clinically meaningful 6.9-point improvement in KCCQ scores

Diabetes 68 , 2133 (2019)

Semaglutide has a half-life of approximately 7 days, so a washout of 2 to 3 weeks allows blood levels to drop to minimal levels

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