P., Burke, K
Diabetology, DNB (Medicine) Consultant Diabetologist, Dr
Is your current dose optimized
Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 ( In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties
Overall, across known regions, Asian patients appeared to have lower GLP1-RA usage (8 to 10%), compared with White (16 to 19%) and Black (13 to 16%) racial groups
Any suspected adverse drug reaction, including a haemolytic episode in a G6PD-deficient patient, should be reported via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk to support ongoing pharmacovigilance
