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doi: 10.1038/s41590-021-00962-w 241 SartoriusR.TrovatoM.MancoR.DApiceL.De BerardinisP
Combining these peptides addresses wound healing from multiple angles: the structural matrix, the cellular migration to fill it, and the blood vessel development to support it
Common contraindications cited in the research-use community include: anyone with active or recent cancer (BPC-157 and TB-500 promote angiogenesis), people with Wilson's disease or other copper-metabolism disorders (GHK-Cu component), anyone pregnant or breastfeeding (no safety data), and athletes subject to WADA testing (BPC-157 and TB-500 are prohibited)
Rat studies using collagen tubes containing GHK-Cu showed increased nerve fiber regeneration, increased axon count, increased Schwann cell proliferation, and restored skin innervation in healing wounds
Nevertheless, the role of building the protein molecules is not the only function of cysteine