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Cureus, 12(5), e8320
High-dose B12 supplements, even 1,000 mcg daily, are generally safe because the body uses what it needs and excretes the rest
PMID:34368359 Kannt A, et al
NAD metabolism and mitochondrial function in obesity
Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption
It also means allergic reactions are unlikely, though not impossible, since any foreign substance can theoretically trigger sensitivity in susceptible individuals
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