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Three meta-analyses concluded that intravenous (IV) NAC significantly decreased the incidence of postoperative AKI after cardiac surgery compared with control [odd ratios (OR) for AKI 0.7 [41], 0.77 [35], and 0.84 [44]]

The ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), expressed on the luminal endothelial plasma membrane, are pivotal in CNS pharmaco-resistance [24, 30,31,32]

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Notably, iron overload, ROS accumulation, abnormal ferroptosis, and inefficient erythropoiesis are all hallmarks of -thalassemia [180]