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Review article: the epidemiology and prevention of gastric cancer

Research on multi-receptor agonists of incretins may further develop the neuroprotective effects of GLP-1 and related drugs

10.1016/j.physbeh.2015.06.013 [DOI] [PMC free article] [PubMed] [Google Scholar] Steinert RE, Peterli R, Keller S, Meyer-Gerspach AC, Drewe J, Peters T, Beglinger C, 2013

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Signs of degradation in lyophilized retatrutide include: color change from white to yellow or brown, collapse or liquefaction of the lyophilized cake, unusual odor upon opening the vial, and failure to dissolve clearly during reconstitution

This acidic formulation, combined with the acylation modification that extends its half-life, likely contributes to local tissue irritation