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9 In pancreatic -cells, GLP-1R signaling recruits contact proteins between the endoplasmic reticulum and mitochondria, such as AKAPs, thereby supporting mitochondrial remodeling and cellular energy homeostasis, processes that are particularly relevant during development (Figure 1, center)

If all goes well, BRP could move into human trials within the next few years

second, it is converted into selenosugars, methylselenide (CH 3 SeH), dimethylselenide ((CH 3 ) 2 Se), and trimethylselenonium ion ((CH 3 ) 3 Se + ), which are primarily excreted through urine, feces, and respiration, with a small portion being excreted through sweat [82]

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