EMT and circulating fibroblasts play a major role in controlling fibrosis, and their biological characteristics will be important to take into account when developing new treatment targets in the future to slow the progression of PF through SalB
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Although this suggests neuroprotective effects of GLP-1, it is not possible in this study to separate protective effects of the mesenchymal stem cells themselves, from the effect of liraglutide, since a non-GLP transfected MSC control was not used
Furthermore, the activation of NADPH oxidases, particularly NOX4, has been identified as a significant source of ROS in diabetic contexts, thereby intensifying oxidative damage to neural tissues (Syed et al., 2023)
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The addition of data from AMPLITUDE-O trial to the seven-trial meta-analysis [5] showed that patients with type 2 diabetes who received GLP-1 agonists had a decreased risk of MACE and decreased individual components (stroke more than myocardial infarction), independently of the structure of these drugs (exendine-4 based or human analogs)
