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The OGDC is very similar to the PDH complex in the intricacy of its protein makeup (E1, E2, and E3 activities), cofactors (TPP, lipoic acid, CoA, FAD, and NAD + ), and its mechanism of action

Therefore, N-acetylcysteine (NAC) is an effective antidote for APAP poisoning because it provides extra cysteines for GSH synthesis in the liver

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