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While the medication can be highly effective for treating ADHD when used appropriately, misuse or high-dose exposure can lead to tolerance, dependence, and addiction

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In a healthy detoxification system, the liver identifies these biotoxins, binds them to antioxidants like glutathione, and excretes them through bile into the digestive tract to be eliminated in stool

We dont know whether that would have had any impact on the measurement

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doi: 10.1073/pnas.1522730113 26 BrownP.BrandelJ