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B12 definitely can do this but it is more common for other B vitamins to do this

Over dozens of injections from a single vial, this dead space adds up

Unlike oral supplements such as tablets, capsules, sprays and tinctures, intravenous (IV) and intramuscular (IM) administration of nutrients bypass the gastrointestinal tract entirely, facilitating the direct delivery of Vitamins and minerals into the bloodstream

Vitamin supplements

Direct the water against the inner wall of the peptide vial as it is injected never onto the lyophilized cake, since direct impact foams the solution and denatures peptide at the air-water interface

But honestly, the biggest mistake people make is waiting too long