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55,58,59 Therefore, NNMT and CYP2E1 divert NAM from recycling to NAD + , restraining NAM accumulation and inhibition of NAD + -dependent signaling

Plant Sci 166(2):451458 Krueger S, Niehl A, Martin MC, Steinhauser D, Donath A, Hildebrandt T, Romero LC, Hoefgen R, Gotor C, Hesse H (2009) Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis

A low ratio may reflect inflammation, cellular aging, or toxin exposure

low background concentrations can be detected in soils, sediments, waters and even in organisms

Maechler et al