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In this review, we discuss the discovery and development of the first rationally designed approach to unimolecular co-agonism, which recruits the well-established pharmacology of glucagon-like peptide 1 (GLP-1) and, counterintuitively, glucagon

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68 HP 125 FRAG 176-191 HGH C-Terminal Fragment Lipolytic Only ALIASES Frag 176-191, HGH Fragment 176-191, AOD-9604 parent fragment, lipolytic HGH C-terminus CLASS Synthetic peptide HGH C-terminal lipolytic fragment FORMULA C78H125N23O23S2 SEQUENCE Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (residues 176-191 of human GH) HALF-LIFE ~30 minutes (rapid plasma clearance) ROUTES Subcutaneous (research) MECHANISM OF ACTION 16-amino-acid C-terminal fragment of human growth hormone (residues 176-191), also known as AOD-9604 in its modified form