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Managing fatigue in cirrhosis encompasses both non-pharmacological and pharmacological strategies

doi: 10.31883/pjfns/109280 8 ButlerN.GhugreP

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According to current guidance: GLP-1 medications are FDA-approved only for adolescents aged 12 and above with severe obesity (defined as a BMI of 120% or more of the 95th percentile)

Due to tirzepatide's long half-life (approximately five days) and delayed peak concentration (8-72 hours after injection), symptoms typically reflect steady-state effects rather than immediate post-injection peaks

Research shows that ongoing GLP-1 receptor stimulation quickly leads to tachyphylaxis of gastric emptying effects [24]