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5 Conclusion Dietary supplementation of kaempferol effectively alleviates oxidative stress in laying hens by reducing hepatic lipid accumulation, serum triglyceride levels, and egg yolk cholesterol content, enhancing antioxidant enzyme (GSH-PX/CAT/SOD) activity and related antioxidant/inflammatory gene ( SOD1 / SOD2 / IL-4 / IL-10 ) expression, and improves immune-inflammatory balance by regulating cytokines (IL-4/IL-1/IL-6) in serum and related cytokine genes ( IL-4 / IL-1 / IL-6 ) in reproductive organs, with the 0.4 g/kg KAE group exhibiting the optimal efficacy

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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration