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Rather than a simple physical advantage in cellcell binding, the proadhesive effect of the presence of knobs may reflect a localized abundance of adhesive ligands and receptors ( ATP and Red Blood Cell-Endothelial Adhesion in Thrombosis Venous thromboses are composed in large part by RBCs, but the role of RBCs in clot formation (and resolution, if any) has been typically viewed as passive

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