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The decision to initiate pharmacotherapy should involve shared decision-making, considering individual patient values, preferences, treatment goals, and cost considerations, as these medications can be expensive and may face insurance coverage limitations

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Mundil D, Cameron-Vendrig A, Husain M

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They soon realised that overproduction of ketones in the body was responsible for the coma, now known as diabetic ketoacidosis (VanItallie, Nufert)

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The mechanism is not fully understood but may relate to changes in blood sugar regulation during sleep or the stimulatory effects of B12 in the compounded formulation