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Amylin analogs for the treatment of obesity without diabetes: present and future

Cytopathol Off J Br Soc Clin Cytol

Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis and FAO 81 resulting in defective cell metabolism and carcinogenesis 82 directly targeting key enzymes or transcription factors as oncogenes and tumor suppressors 81 as shown in Table 1

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It helps optimize neurotransmitter production, supporting focus and motivation while reducing cravings triggered by stress or fatigue

Pharmacological inhibition of TMA lyase by 3,3-dimethyl-1-butanol (DMB) in imiquimod-induced lupus models demonstrates multi-organ protection through TMAO suppression, including endothelial function restoration and macrophage foam cell formation inhibition independent of cholesterol modulation ( Complementary studies reveal diverse TMAO modulation strategies: Puerarin exerts atheroprotection via Prevotella copri depletion and TMA precursor reduction, while berberines vitamin-mimetic metabolite dihydroberberine disrupts gut microbial TMA biosynthesis (165, 166)