The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds
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Haptoglobin and hemopexin molecules circulating in blood scavenge Hb and heme, respectively, to reduce their toxicity [223]
In this case, 69.7% of the placebo group developed peripheral neuropathy, while only 52.2% in the supplemented group experienced the same issue, showing a significant difference between both groups ( p = 0.017) [152] Table 1
However, given the inconsistency and heterogeneity of findings, it can be inferred that the effects may vary between different UGT isoforms (Collier et al., 2002
A clinician should also match the setting to the complexity of the case