For the GLP-1R V229A, however, we observed a higher proportion of receptors pre-existing as higher order oligomers under vehicle conditions, with no further increases after exendin-4 stimulation, indicating that the mutant receptor has a higher clustering propensity in the inactive state
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Now, the World Health Organization (WHO) has released new global guidelines recognizing obesity as a chronic disease and formally supporting the long-term use of GLP-1 therapies for weight management