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This case particularly highlights an uncommon presentation with hypercalcemia and cutaneous metastases that may not be recognized as a manifestation of CCS by an oncologist who does not specialize in sarcomas

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Masciulli A, Ferrari A, Carobbio A, Ghirardi A, Barbui T

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Both open (Protein Data Bank (PDB) 3KAK) and closed (PDB 3KAL) active site forms of hGSH synthetases have been crystallized, with the phosphorylation and amide bond-forming steps proposed to be catalyzed in the closed form 52

Without adequate protein, your body will break down muscle tissue to meet its amino acid requirements