demonstrated in rats that Mn accumulates in the dopaminergic cells of the substantia nigra pars compacta, at around 40200 M (Robison et al., 2015)
Additionally, while our Co-IP assay demonstrated a physical interaction between SIRT5 and TFR1, the use of a more spatially sensitive technique, such as Proximity Ligation Assay (PLA), would provide stronger in situ evidence for their direct interaction
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Referral to memory services may be indicated following initial assessment
Mild side effects may include pain at the injection site, nausea, or dizziness
All of these compliance and operational requirements impose significant costs, such as costs related to organizational changes, implementing additional protection technologies, training employees and engaging consultants and legal advisors, which are likely to increase over time