The TRIUMPH Phase 3 clinical programme is ongoing
A slower escalation may be needed if side effects are troublesome Eat smaller, more frequent meals and avoid high-fat foods Stay well hydrated, particularly if experiencing vomiting or diarrhoea, to reduce the risk of dehydration and acute kidney injury Take the injection at a consistent time that minimises symptom impact Treatment continuation criteria , aligned with NICE guidance (TA664), recommend: Assessing weight loss after 12 weeks at the 3.0 mg maintenance dose Continuing treatment only if at least 5% of initial body weight has been lost Discontinuing Saxenda if adequate weight loss is not achieved or maintained Treatment typically limited to up to 2 years within specialist weight management services Patient safety considerations include proper injection technique, rotating injection sites to prevent lipodystrophy, and appropriate medication storage (refrigerated before first use, then at room temperature for up to one month)
Determination of SIRT1 level The level of SIRT1 was measured in liver homogenate using a mouse-specific ELISA kit (MyBiosource, San Diego, USA
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Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets
