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Accordingly, replacing the methoxy group with ethoxy chain 4i did improve the inhibitory potency significantly (IC 50 = 1.58 2.76 M) which was around sixfold more potent than reference drug kojic acid

This modulation of gene expression linked to inflammation and healing processes underscores its potential as a versatile therapeutic agent

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The solutions were added to the 96-well plates in 100 L aliquots and 100 L of buffer was added as a control to give a final drug compound concentration range of 0 100 M

Other products that are in mid- to late-stage studies for NASH are Zealand Pharma & Boehringer Ingelheims dapiglutide & survodutide (BI 456906) as well as Altimmunes pemvidutide