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Sleep quality can drop

Some individuals have genetic variants in the GLP1R gene (such as rs6923761) that affect receptor sensitivity, meaning they experience more pronounced nausea or fullness from sugar, while others have variants in FTO or MC4R genes that influence baseline hunger and satiety set points

Doses and half-lives are conventions, not pharmacology

Moreover, poison control centers report nearly a 1,500 percent increase in calls since 2019 related to overdosing or side effects of injectable GLP-1 usage

The SUSTAIN clinical trial programme, which informed NICE guidance (NG28), demonstrated mean HbA1c reductions of 1.01.5% (1116 mmol/mol) at 30 weeks, depending on the dose used

doi: 10.1016/j.metabol.2014.02.009 44