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The CHALLENGE study randomized 889 patients with resected colon cancer (stage III or high-risk stage II) who had completed adjuvant chemotherapy to a structured exercise program with required visits over 3 years (exercise group) or general health-education materials (control group)

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The human thyroid gland differs from rodents in several key aspects, including a lower density of GLP-1 receptors on C-cells, which are responsible for calcitonin production

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doi:10.1186/s10194-016-0652-7 Merck Manual