Understanding GLP-1 Medications Semaglutide and tirzepatide are injectable glucose- and weight-management therapies that act on incretin pathways to lower blood sugar and reduce appetite
Special situations and considerations Injecting during weight loss As you lose weight on retatrutide, your body composition changes
High cost and insurance challenges
Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus 37 and studies indicate they could be used in other indications 26,43,44 such as obesity 45,46 , adverse cardiovascular events 25 , cognitive disorders 44 and non-alcoholic steatohepatitis (NASH) 47
A separate Phase 2 trial also published in The New England Journal of Medicine in 2023 evaluated retatrutide in adults with type 2 diabetes, reporting meaningful reductions in HbA1c alongside weight loss, with hypoglycaemia rates that were low in the absence of insulin or sulfonylurea co-administration
Subcutaneous injection sites include the abdomen (at least two inches from the navel), outer thigh, and back of the upper arm