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Mitral Cells of the Olfactory Bulb Perform Metabolic Sensing and Are Disrupted by Obesity at the Level of the Kv1.3 Ion Channel
Jan 21, 2026 12 min read IN THIS ARTICLE KEY TAKEAWAYS Weight loss includes both fat mass and lean muscle mass unless muscle is actively preserved
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Brainstem preproglucagon expressing fibers project to many areas of the brain with the most abundant projections to areas hypothalamic areas that control energy homeostasis including the arcuate nucleus (ARC), paraventricular nucleus (PVN), and dorsomedial nucleus (DMH) (Jin et al., 1988)
This dependency concern is one of the primary criticisms of pharmaceutical GLP-1 treatment, and it drives many people to explore alternatives