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Based on our experiment, hiPSCs-derived MVs caused no significant alteration in transcriptions of Sox9 and Oct4 during the 5-day treatment (Fig

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One way to test for these types of effects is to compare a chronic gene deficiency with acute knockdown experiments and if the results are different, adaptive responses likely impacted the injury mechanism [153]

However, in this context, it is essential to keep in mind the possibility that the risk is dose-dependent or higher in certain groups, such as the elderly