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These differences underscore the difficulty in defining HFimpEF, complicating efforts to standardize diagnosis, assess prognosis, and guide therapy across different healthcare settings

S2CID 240072540

Selhub et al, 1995

The time interval between bariatric surgery and the initiation of GLP-1RAs treatment ranged from 12 to 100.8 months, and the duration of GLP-1RA therapy varied from 3 to 12 months

doi: 10.1016/j.fitote.2010.05.001 152 PatraJKDasGFracetoLFCamposEVRRodriguez-Torres M delPAcosta-TorresLSet al

While Semaglutide primarily targets one receptor (GLP-1), Retatrutide must maintain a specific configuration to satisfy three different binding pockets