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320 These observations were confirmed in ob/ob mice and high-fat-fed mice when they were treated with a GIPR antagonist, and also in mice lacking GIP-secreting K cells, confirming the important role of GIP in fat accumulation

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Pimenta F, Maroco J, Ramos C, Leal I

Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

While results vary, many clinical trials and real-world reports confirm that GLP-1 medications like Semaglutide can provide sustainable outcomes when integrated into a long-term weight management plan