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Other studies show that calcium oxide crystals induce mitochondrial dysfunction in macrophages.[ref][ref] High dietary oxalate intake causes some, but not all, people to have statistically significant decreases in mitochondrial metabolic function.[ref] Animal models of high oxalate levels show that there is an increase in mitochondrial reactive oxygen species (ROS) that can lead to oxidative stress if glutathione is inadequate

As an antioxidant, it helps neutralize free radicals, which are unstable molecules produced during metabolic processes

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