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Dual activation (tirzepatide) adds metabolic benefits that translate to roughly 30-50% more weight loss

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Some patients find evening injections allow them to sleep through initial side effects

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Lilly announced results from its Phase 3 TRIUMPH-4 trial of retatrutide, a first-in-class GIP, GLP-1 and glucagon triple hormone receptor agonist, on Thursday

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But the marginal benefit over 8mg is small, and the marginal cost in side effects is real

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