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Intriguingly, a post hoc analysis of a phase 2 clinical trial revealed that dulaglutide treatment resulted in reductions in apoC-III and apoB levels without impacting serum LPL level, whereas treatment with tirzepatide showed a dose-dependent increase in serum LPL activity while concurrently reducing apoC-III and apoB levels (180)

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[13] This warning is based on rodent studies

Medicaid policies vary by state, with 13 states covering GLP-1s for obesity as of August 2024

Activation of GLP-1R ameliorated these memory deficits through regulation of adenosine monophosphate-activated protein kinase (AMPK) and nuclear factor-B (NF-B) pathway, reducing hippocampal neuroinflammation