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Furthermore, limited diagnostic capabilities, difficulty in identifying eligible patients, and variability in disease progression collectively contribute to low enrollment rates, prolonged study timelines, and compromised data integrity in rare disease trials, ultimately resulting in higher failure rates compared to non-rare disease trials 5,6

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Yes, but avoid eyes and use gently

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In its natural form, PEA is not absorbed by the gastrointestinal tract. Coluzzi points out you must purchase PEA that has been ultra-micronized, which is a process that reduces the particle size to enhance absorption