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Additionally, the Hevin-regulated neurexin-related mechanisms were further enhanced by the discovery of the secreted protein acidic and rich in cysteine (SPARC), which is reciprocally antagonistic to neurexins binding, and MAM domain-containing GPI anchor (MDGA), which is reciprocally antagonistic to neuroligins binding in the neurexins-neuroligins transsynaptic complex [91]

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