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Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, Laframboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z (2016) Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Based on preclinical and early human data, GIP may also influence fat metabolism and energy homeostasis, potentially contributing to tirzepatide's weight loss effects

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Some patients may need long-term treatment, while others can transition to weight maintenance strategies once they reach their goal weight