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Studies show that single-molecule dual GIPR/GLP-1R agonists have better insulinotropic and antihyperglycemic effects than GLP-1 agonists in rodents, primates, and humans, without causing gastrointestinal disturbances [58]
The use of GLP-1 analogues during pregnancy is generally not recommended due to limited safety data
Providing your body with nutrients like vitamins A, C, D, and zinc can give it a solid foundation of immune support
Tursi, S
Some patients have already reached their goal weight and are looking to maintain their results while continuing to support metabolic health
Conclusions/interpretation As metformin modulates multiple components of the incretin axis, and enhances expression of the Glp1r and related insulinotropic islet receptors through a mechanism requiring PPAR-, metformin may be mechanistically well suited for combination with incretin-based therapies
